adverb; adjective; noun

Toward the southern or lower-numbered-street direction in Manhattan; it can also refer to Lower Manhattan or other context-specific central areas.

““The downtown platform is across the station.””

The part of New York State north of the speaker’s downstate reference point, with a boundary that New Yorkers famously disagree about.

““They rented a cabin upstate for the weekend.””

Toward the northern or higher-numbered-street direction in Manhattan; it can also name particular northern areas depending on context.

““Take the uptown train two stops.””